PT Journal AU Visnovcova, Z Tonhajzerova, I TI Biomedical principle and application of electrodermal response in clinical practice SO Cognitive Remediation Journal PY 2013 BP 10 EP 15 VL 2 IS 1 DI 10.5507/crj.2013.002 DE Electrodermal activity; ADHD; depression AB Electrodermal activity (EDA) allows to evaluate the changes of the sympathetic nervous system during various psychological states by noninvasive approach. Sympathetic overactivity is associated with higher risk of cardiovascular morbidity. Therefore, it is very important to understand of the EDA biomedical principle for following correct evaluation in clinical practice. The aim of this study was to provide the biomedical principle of EDA with clinical application in mental disorders.Methods: The principle of EDA is based on record of electrical variation on the body surface. Skin represents relatively a nonconductive layer. Sweating provides the change of this non-conductor layer of skin to conductive, so it allows recording of the skin conductance - electrodermal activity. This noninvasive marker of sympathetic activity can be used in stress profile, and in clinical practice (depression, ADHD) from the point of cardiovascular risk.Conclusion: EDA represents non-invasive method for monitoring psychological process, which take place in the human body. It is assumed that EDA recording can contribute to early diagnosis and therapeutic interventions of cardiovascular dysregulation in mental disorders. ER