PT  - JOURNAL ARTICLE
AU  - Bujnakova, Iveta
AU  - Ondrejka, Igor
AU  - Mestanik, Michal
AU  - Tonhajzerova, Ingrid
TI  - Autonomic nervous system in children with autism spectrum disorder
DP  - 2015 Oct 15
TA  - Cognitive Remediation Journal
PG  - 4--17
VI  - 4
IP  - 2
AID - 10.5507/crj.2015.003
IS  - 18057225
AB  - Background. Autism spectrum disorder (ASD) is a neurodevelopmental disorder of unknown etiology, defined by impaired social communication and interaction, and by the presence of restrictive and repetitive behaviour. The autonomic imbalance, in which one branch of the autonomic nervous system (ANS) dominates over the other, is associated with a lack of dynamic flexibility and adaptability. The aim of this article was to summarize the current state of knowledge regarding ANS activity in children with ASD.Methods and Results. We have collected the latest information on autism and ANS regulation from available medical resources (PubMed). We focused on two main physiological parameters such as heart rate variability (HRV) and electrodermal activity (EDA) as the noninvasive indices of vagal and sympathetic activity, respectively. The studies showed atypical autonomic activity at rest as well as in response to stress.Conclusion. ASD symptoms are associated with pervasive abnormalities in the central nervous system including structures and networks involved in the complex ANS regulation. Importantly, the autonomic imbalance in a manner of higher sympathetic activity associated with lower vagal activity is associated with increased risk of cardiovascular, and other adverse outcomes in ASD. Therefore, we suggest that detailed complex analysis of physiological parameters may illuminate the pathway linking ASD and autonomic nervous system activity.